Compound ID | 3152

Update compound information

1-Deamino-1-hydroxyxylostasin

Synonym(s): S-11-A

Class: Aminoglycoside

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Klebsiella pneumoniae, and susceptible and AAC(3)-II-expressing Escherichia coli
Description: Natural product from a 2-deoxystreptamine negative (DOS-) Bacillus circulans
Institute where first reported: Shionogi Research Laboratory, Shionogi & Co., Ltd.
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 455.46
Iso. SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H](O2)CO)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)N)N
InChI Key: PPSXCTHLNCODRT-YWBRTWDRSA-N
Can. SMILES: C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1O)O)O[C@H]2[C@@H]([C@H]([C@@H](CO)O2)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@@H](CN)O3)O)O)N)N
InChI: InChI=1S/C17H33N3O11/c18-2-6-10(24)12(26)8(20)16(28-6)30-14-4(19)1-5(22)9(23)15(14)31-17-13(27)11(25)7(3-21)29-17/h4-17,21-27H,1-3,18-20H2/t4-,5+,6+,7+,8+,9-,10+,11-,12+,13+,14+,15+,16+,17-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/101283399
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/33/8/33_8_836/_article/-char/en

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