Compound ID | 3154

Update compound information

Bu-2545

Synonym(s): Bu 2545

Class: Lincosamide

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Binds to peptidyl transferase domain of the 50S ribosomal subunit
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium perfringens, and Propionibacterium acnes
Description: Natural product from Streptomyces sp.
Institute where first reported: Bristol-Banyu Research Institute, Ltd.
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 378.49
Iso. SMILES: CC(C(C1C(C(C(C(O1)SC)O)O)O)NC(=O)C2CCCN2C)OC
InChI Key: WVXCVWNSJUNIRQ-UHFFFAOYSA-N
Can. SMILES: CC(C(C1C(C(C(C(O1)SC)O)O)O)NC(=O)C2CCCN2C)OC
InChI: InChI=1S/C16H30N2O6S/c1-8(23-3)10(17-15(22)9-6-5-7-18(9)2)14-12(20)11(19)13(21)16(24-14)25-4/h8-14,16,19-21H,5-7H2,1-4H3,(H,17,22)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/173326
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547251/
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/7/33_7_751/_article/-char/en

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