Compound ID | 3159

Update compound information

Bu-2313

Synonym(s): Bu 2313  |  Bu-2313 A

Class: Aminoglycoside

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, and anaerobic bacteria
Description: Natural product from Microtetraspora caesia; rescues mice from Streptococcus pyogenes infection when administered subcutaneously (protective dose at 7.6 mg/kg vs lethal dose 90mg/kg)
Institute where first reported: Bristol-Banyu Research Institute, Ltd.
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 517.57
Iso. SMILES: C[C@H]1[C@@H]2C(=O)C[C@]3([C@@](O2)([C@H]([C@H](O3)C)C(=O)OC)O[C@@H]1[C@H](C)/C=C(\C)/C=C/C(=C/4\C(=O)CN(C4=O)C)/O)C
InChI Key: GJDWUPRATYQDKW-VCAHYFOQSA-N
Can. SMILES: C/C(=C\[C@@H](C)[C@@H]1[C@@H](C)[C@@H]2C(=O)C[C@@]3(C)[C@@]([C@H]([C@@H](C)O3)C(=O)OC)(O1)O2)/C=C/C(=C/4\C(=O)CN(C)C4=O)/O
InChI: InChI=1S/C27H35NO9/c1-13(8-9-17(29)20-19(31)12-28(6)24(20)32)10-14(2)22-15(3)23-18(30)11-26(5)27(36-22,37-23)21(16(4)35-26)25(33)34-7/h8-10,14-16,21-23,29H,11-12H2,1-7H3/b9-8+,13-10+,20-17-/t14-,15-,16-,21-,22-,23-,26+,27+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54724550
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/2/33_2_173/_article/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/2/33_2_157/_article/-char/en

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