Compound ID | 3161

Update compound information

Clazamycin B

Synonym(s): Antibiotic 354

Class: Membrane-active agent

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. Disrupts integrity of cell membrane
Target Pathogen: Active against Salmonella typhi, Pseudomonas aeruginosa, and Shigella sp.
Description: Natural product from Streptomyces puniceus subsp. doliceus; chlorine-containing compound
Institute where first reported: The Upjohn Company, Research Laboratories
Year first mentioned: 1979
Development status: Experimental
Chemical structure(s):
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Molecular weight: 172.61
Iso. SMILES: C1[C@@H](CN2[C@]1(C=CC2=N)O)Cl
InChI Key: DVCHIDKMDZZKBR-CAHLUQPWSA-N
Can. SMILES: C1=C[C@]2(C[C@@H](CN2C1=N)Cl)O
InChI: InChI=1S/C7H9ClN2O/c8-5-3-7(11)2-1-6(9)10(7)4-5/h1-2,5,9,11H,3-4H2/t5-,7+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/126335
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/1/33_1_83/_article/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/32/7/32_7_762/_article

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