Compound ID | 3163

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Dnacin B1

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhimurium; DNA synthesis inhibitor
Description: Natural product from Nocardia sp.; a benzoquinoid antibiotic
Institute where first reported: Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 388.42
Iso. SMILES: CN1C2CC3C1C4C(C5=C(C(N4C2O)CO)C(=O)C(=CC5=O)N)N6C3OCC6
InChI Key: BJHZMIHVUMIBSL-UHFFFAOYSA-N
Can. SMILES: CN1C2CC3C1C4C(C5=C(C(CO)N4C2O)C(=O)C(=CC5=O)N)N6CCOC36
InChI: InChI=1S/C19H24N4O5/c1-21-9-4-7-14(21)16-15(22-2-3-28-19(7)22)13-11(25)5-8(20)17(26)12(13)10(6-24)23(16)18(9)27/h5,7,9-10,14-16,18-19,24,27H,2-4,6,20H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3086066
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC185654/
  • https://www.jstage.jst.go.jp/article/antibiotics1968/33/12/33_12_1443/_article/-char/en

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