Compound ID | 3164

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Antibiotic 6016

Class: Membrane-active agent

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Membrane-active agent. Disrupts integrity of cell membrane
Target Pathogen: Active against Staphylococcus aureus, Mycobacterium avium, and Mycobacterium smegmatis
Description: Natural product from Streptomyces albus; a polyether ionophore
Institute where first reported: Central Research Laboratories, Kaken Chemical Co., Ltd.
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 887.1
Iso. SMILES: CC1CC(C(OC1C2CCC(O2)C3CC(C(O3)C4(CC(C5(O4)C(C(CC(O5)CC6C(C(C(C(O6)(C(C(=O)O)O)O)C)OC)C)OC)C)C)C)OC7CCC(C(O7)C)OC)(C)O)C
InChI Key: AINDPXHXPBFFDG-UHFFFAOYSA-N
Can. SMILES: CC1CC(C)C(C)(O)OC1C2CCC(C3CC(C(C4(C)CC(C)C5(C(C)C(CC(CC6C(C)C(C(C)C(C(C(=O)O)O)(O)O6)OC)O5)OC)O4)O3)OC7CCC(C(C)O7)OC)O2
InChI: InChI=1S/C46H78O16/c1-22-17-23(2)44(9,50)61-38(22)32-14-13-31(56-32)35-20-36(57-37-16-15-30(52-10)28(7)55-37)41(58-35)43(8)21-24(3)46(62-43)26(5)34(53-11)19-29(59-46)18-33-25(4)39(54-12)27(6)45(51,60-33)40(47)42(48)49/h22-41,47,50-51H,13-21H2,1-12H3,(H,48,49)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/172407
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/33/12/33_12_1437/_article/-char/en

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