Compound ID | 3179

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Haloquinone

Class: Natural product antibiotic

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Proteus sp., Mycobacterium sp., Streptococcus faecalis, and Staphylococcus aureus; likely DNA synthesis inhibitor by DNA intercalation; membrane-active agent
Description: Natural product from Streptomyces venezuelae ssp. xantlzophaeus; also shows anti-tumour activity
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
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Molecular weight: 296.27
Iso. SMILES: CC1=C(C=C2C3=C(C(=CC=C3)O)C(=O)C(=O)C2=C1O)C(=O)C
InChI Key: CPYFLMXPZMBECD-UHFFFAOYSA-N
Can. SMILES: CC1=C(C=C2C3=C(C(=CC=C3)O)C(=O)C(=O)C2=C1O)C(=O)C
InChI: InChI=1S/C17H12O5/c1-7-10(8(2)18)6-11-9-4-3-5-12(19)13(9)16(21)17(22)14(11)15(7)20/h3-6,19-20H,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/133561
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/34/12/34_12_1531/_article

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