Compound ID | 3181

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Pyrrolomycin B

Synonym(s): SF-2080 B  |  SF2080 B  |  SF 2080 B

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Membrane-active agent. Depolarizes cell membrane
Target Pathogen: Active against Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa
Description: Natural product from Streptomyces sp.; a protonophore
Institute where first reported: Central Research Laboratories, Meiji Seika Kaisha, Ltd.
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
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Molecular weight: 355.99
Iso. SMILES: C1=C(C=C(C(=C1CC2=C(C(=C(N2)Cl)Cl)[N+](=O)[O-])O)Cl)Cl
InChI Key: ZIOBWQJYKHDNKP-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1CC2=C(C(=C(Cl)N2)Cl)[N+](=O)[O-])O)Cl)Cl
InChI: InChI=1S/C11H6Cl4N2O3/c12-5-1-4(10(18)6(13)3-5)2-7-9(17(19)20)8(14)11(15)16-7/h1,3,16,18H,2H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/133274
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/34/10/34_10_1363/_article

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