Compound ID | 3189

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Antibiotic U-62162

Synonym(s): Antibiotic U62162  |  Antibiotic U 62162

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Likely targets elongation factor (EF) Tu
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from Streptomyces verdensis; does not rescue mice infected with Staphylococcus aureus
Institute where first reported: Research Laboratories, The Upjohn Company
Year first mentioned: 1982
Development status: Experimental
Chemical structure(s):
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Molecular weight: 419.51
Iso. SMILES: CC(CC(C)C=C(C)C)/C=C/C(=O)NC1=CC(C2C(C1=O)O2)(CCCCC(=O)O)O
InChI Key: PZLHSEIQCKXDHC-CMDGGOBGSA-N
Can. SMILES: CC(=CC(C)CC(C)/C=C/C(=O)NC1=CC(CCCCC(=O)O)(C2C(C1=O)O2)O)C
InChI: InChI=1S/C23H33NO6/c1-14(2)11-16(4)12-15(3)8-9-18(25)24-17-13-23(29,10-6-5-7-19(26)27)22-21(30-22)20(17)28/h8-9,11,13,15-16,21-22,29H,5-7,10,12H2,1-4H3,(H,24,25)(H,26,27)/b9-8+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6439619
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/35/4/35_4_436/_pdf/-char/en
  • https://www.jstage.jst.go.jp/article/antibiotics1968/35/5/35_5_556/_article/-char/en

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