Delamanid

Synonym(s): OPC-67683

Class: Nitroimidazole

Details of activity:	Active against Mycobacterium tuberculosis; inhibits synthesis of methoxy mycolic acid and ketomycolic acid
Description:	Synthetic compound; nitro-dihydro-imidazooxazole derivative
Institute where first reported:	Otsuka Pharmaceutical
Year first mentioned:	2006
Highest developmental phase:	Phase 3 (NCT01424670)
Development status:	Active (as of 2024)

Chemical structure(s):
Canonical SMILES:	C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F
Isomeric SMILES:	C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F
InChI:	InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
InChI Key:	XDAOLTSRNUSPPH-XMMPIXPASA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6480466

External links:
Guide to Pharmacology:	delamanid
Main Source:	https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0030466