Compound ID | 320

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Research Programme-2-(Thiazol-2ylthio)-1β-Methylcarbapenem: SM-232724

Class: Beta-lactam (carbapenem)

Spectrum of activity: Gram-negative
Details of activity: Cell wall inhibitor; Good activity against drug resistant infections including MRS and VRE
Institute where first reported: Roche, Switzerland; Sumitomo Pharmaceuticals (Dainippon Sumitomo Pharmaceuticals, Japan)
Year first mentioned: 2001
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 421.54
Iso. SMILES: C[C@@H]1CC(=CCN1)C2=CSC(=N2)SC3=C(N4[C@H]([C@H]3C)[C@H](C4=O)[C@@H](C)O)C(=O)O
InChI Key: CYZBHVGPRYZKQN-DRDKAZGBSA-N
Can. SMILES: C[C@@H]1CC(=CCN1)C2=CSC(=N2)SC3=C(C(=O)O)N4[C@H]([C@H]3C)[C@@H]([C@@H](C)O)C4=O
InChI: InChI=1S/C19H23N3O4S2/c1-8-6-11(4-5-20-8)12-7-27-19(21-12)28-16-9(2)14-13(10(3)23)17(24)22(14)15(16)18(25)26/h4,7-10,13-14,20,23H,5-6H2,1-3H3,(H,25,26)/t8-,9-,10-,13-,14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11037227
Citation: https://journals.asm.org/doi/10.1128/aac.47.8.2471-2480.2003

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