Compound ID | 320

Update compound information

SM-232724

Synonym(s): Research Programme-2-(Thiazol-2ylthio)-1β-Methylcarbapenem  |  SM 232724  |  SM232724

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci
Description: A 1 beta-methylcarbapenems with a unique 4-substituted thiazol-2-ylthio moiety
Institute where first reported: Roche, Switzerland; Sumitomo Pharmaceuticals (Dainippon Sumitomo Pharmaceuticals, Japan)
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 421.54
Iso. SMILES: C[C@@H]1CC(=CCN1)C2=CSC(=N2)SC3=C(N4[C@H]([C@H]3C)[C@H](C4=O)[C@@H](C)O)C(=O)O
InChI Key: CYZBHVGPRYZKQN-DRDKAZGBSA-N
Can. SMILES: C[C@@H]1CC(=CCN1)C2=CSC(=N2)SC3=C(C(=O)O)N4[C@H]([C@H]3C)[C@@H]([C@@H](C)O)C4=O
InChI: InChI=1S/C19H23N3O4S2/c1-8-6-11(4-5-20-8)12-7-27-19(21-12)28-16-9(2)14-13(10(3)23)17(24)22(14)15(16)18(25)26/h4,7-10,13-14,20,23H,5-6H2,1-3H3,(H,25,26)/t8-,9-,10-,13-,14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11037227
Citation: https://journals.asm.org/doi/10.1128/aac.47.8.2471-2480.2003

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.