Compound ID | 3201

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Protionamide

Synonym(s): Prothionamide

Class: Mycolic acid synthesis inhibitor

Details of activity: Active against tuberculous and non-tuberculous mycobacterial infections; mycolic acid synthesis inhibitor (binds to enoyl-acyl ACP reductase InhA)
Description: Synthetic compound; pyridine derivative of ethionamide; may be included in treatment of MDR or rifampicin resistant TB (second-line anti-TB drug)
Year first mentioned: 1950
Highest developmental phase: Phase 3 (NCT06081361)
Development status: Active (as of 2024)
Chemical structure(s):
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Molecular weight: 180.27
Iso. SMILES: CCCC1=NC=CC(=C1)C(=S)N
InChI Key: VRDIULHPQTYCLN-UHFFFAOYSA-N
Can. SMILES: CCCC1=CC(=CC=N1)C(=S)N
InChI: InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/666418
Citation: https://www.sciencedirect.com/science/article/pii/0041387968900482?via%3Dihub

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