Cefpirome

Synonym(s): HR-810  |  HR810

Class: Beta-lactam (cephalosporin, fourth-generation)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Staphylococcus aureus, Enterobacter cloacae, Streptococcus sp., Pseudomonas aeruginosa;
Description:	Synthetic compound derived from cephalosporin C; shows synergistic effect with gentamicin in Pseudomonas and Enterobacter strains
Institute where first reported:	Hoechst AG
Year first mentioned:	1983
Highest developmental phase:	Approved (not in US)
Development status:	Approved
Reason Dropped:	Discontinued in many countries

Chemical structure(s):
Canonical SMILES:	CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4=C5CCCC5=CC=C4)CS[C@H]23)C(=O)[O-]
Isomeric SMILES:	CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCC5)C(=O)[O-]
InChI:	InChI=1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20-/m1/s1
InChI Key:	DKOQGJHPHLTOJR-WHRDSVKCSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5479539

External links:
Main Source:	https://www.jstage.jst.go.jp/article/antibiotics1968/37/8/37_8_929/_article/-char/en
Citations:	https://pubmed.ncbi.nlm.nih.gov/1601761/ https://pubmed.ncbi.nlm.nih.gov/9211085/ https://pubmed.ncbi.nlm.nih.gov/8261711/