Compound ID | 3251

Update compound information

U-68,204

Synonym(s): U-68204  |  U68204

Class: Natural product antibiotic (thiolactone-containing antibiotic)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, and Bacteroides fragilis
Description: Natural product from Streptomyces thiolactonus; protects mice from Haemophilus influenzae but not multidrug-resistant Staphylococcus aureus infection at 50 mg/kg; a thiolactone-containing antibiotic
Institute where first reported: Infectious Diseases Research, The Upjohn Company Kalamazoo, Michigan 49001, U.S.A
Year first mentioned: 1986
Development status: Experimental
Chemical structure(s):
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Molecular weight: 267.35
Iso. SMILES: CC[C@]1(C(=C(C(=O)S1)CC(=O)N)O)/C=C(\C)/C=C
InChI Key: UABLTRHPBMADHP-SBDDDAINSA-N
Can. SMILES: C=C/C(=C/[C@]1(CC)C(=C(CC(=O)N)C(=O)S1)O)/C
InChI: InChI=1S/C13H17NO3S/c1-4-8(3)7-13(5-2)11(16)9(6-10(14)15)12(17)18-13/h4,7,16H,1,5-6H2,2-3H3,(H2,14,15)/b8-7+/t13-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135754250
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/39/1/39_1_26/_pdf/-char/en

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