Compound ID | 3256

Update compound information

Danofloxacin

Synonym(s): Advocin  |  CP-76,136  |  CP-76136  |  CP 76,136  |  CP 76136  |  CP76136  |  CP76,136  |  CP 76 136

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against Escherichia coli, Salmonella choleraesuis, and Staphylococcus aureus
Description: Synthetic compound; intended for veterinary use
Year first mentioned: 1990
Development status: Experimental
Chemical structure(s):
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Molecular weight: 357.38
Iso. SMILES: CN1C[C@@H]2C[C@H]1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F
InChI Key: QMLVECGLEOSESV-RYUDHWBXSA-N
Can. SMILES: CN1C[C@@H]2C[C@H]1CN2C3=CC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(=O)O
InChI: InChI=1S/C19H20FN3O3/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26)/t11-,12-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71335
Guide to Pharmacology: danofloxacin
Citations:
  • https://pubs.acs.org/doi/abs/10.1021/jm00082a001
  • https://bvajournals.onlinelibrary.wiley.com/doi/10.1136/vr.154.19.585

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