Compound ID | 3263

Update compound information

Tildipirosin

Class: Macrolide

Spectrum of activity: Gram-negative
Details of activity: Indicated for bovine and swine respiratory tract infections; protein synthesis inhibitor (binds to peptidyl transferase centre to prevent translocation)
Description: Semi-synthetic compound; derived from tylosin
Year first mentioned: 2012
Highest developmental phase: Approved for veterinary use
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 734.02
Iso. SMILES: CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3CCCCC3)C)\C)CN4CCCCC4
InChI Key: HNDXPZPJZGTJLJ-UEJFNEDBSA-N
Can. SMILES: CC[C@@H]1[C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@H](CCN2CCCCC2)[C@@H]([C@@H](C)[C@@H](CC(=O)O1)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](C)O3)O)N(C)C)O)CN4CCCCC4
InChI: InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+,27-23+/t28-,29+,30-,31+,32-,34-,35-,37+,38-,39-,40-,41+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/24860548
Guide to Pharmacology: tildipirosin
Citations:
  • https://journals.asm.org/doi/10.1128/aac.01250-12
  • https://pubs.acs.org/doi/10.1021/cb300105p

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