Compound ID | 3267

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Cefroxadine

Synonym(s): CGP-9000  |  CGP9000  |  CGP 9000

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus, Escherichia coli, Salmonella spp., and Klebsiella pneumoniae; susceptible to hydrolysis by cephalosporinases
Description: Synthetic compound; a dihydrophenylglycin derivative of 7-amino-cephalosporanic acid; an orally active cephalosporin; shows better protection than cephalexin in mice infected with Escherichia coli or Pseudomonas aeruginosa
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 365.41
Iso. SMILES: COC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CCC=CC3)N)SC1)C(=O)O
InChI Key: RDMOROXKXONCAL-UEKVPHQBSA-N
Can. SMILES: COC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)[C@@H](C3=CCC=CC3)N
InChI: InChI=1S/C16H19N3O5S/c1-24-9-7-25-15-11(14(21)19(15)12(9)16(22)23)18-13(20)10(17)8-5-3-2-4-6-8/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5284529
Guide to Pharmacology: cefroxadine
Citation: https://journals.asm.org/doi/10.1128/aac.18.1.105

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