Compound ID | 327

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BO-1341

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Pseudomonas aeruginosa
Description: Cephalosporin-type with 6,7-dihydroxy-isoqui-nolinium moiety
Institute where first reported: Banyu Pharmaceutical Co. Ltd., (Merck & Co, USA)
Year first mentioned: 1987
Development status: Experimental
Reason dropped: Possibly due to resistance development/discovery in Pseudomonas sp.
Chemical structure(s):
Click here for structure editor
Molecular weight: 628.64
Iso. SMILES: CC(C)(C(=O)O)O/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC5=CC(=C(C=C5C=C4)O)O)C(=O)[O-]
InChI Key: XMOLQYFYIRKUAY-PLEZTBHSSA-N
Can. SMILES: CC(C)(C(=O)O)O/N=C(\C1=CSC(=N1)N)/C(=O)N[C@@H]2C(=O)N3C(=C(C[N+]4=CC=C5C=C(C(=CC5=C4)O)O)CS[C@H]23)C(=O)[O-]
InChI: InChI=1S/C26H24N6O9S2/c1-26(2,24(39)40)41-30-17(14-10-43-25(27)28-14)20(35)29-18-21(36)32-19(23(37)38)13(9-42-22(18)32)8-31-4-3-11-5-15(33)16(34)6-12(11)7-31/h3-7,10,18,22H,8-9H2,1-2H3,(H6,27,28,29,34,35,37,38,39,40)/b30-17+/t18-,22-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9577438
Citations:
  • https://academic.oup.com/jac/article-abstract/29/3/287/658193/Resistance-to-a-new-catecholic-cepbem-BO-1341-in?redirectedFrom=fulltext
  • http://www.ncbi.nlm.nih.gov/pubmed/1592698
  • https://doi.org/10.1128/aac.33.9.1423

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