Phthalylsulfathiazole

Synonym(s): sulfathalidine

Class: Sulfa drug / Sulphonamide

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Escherichia coli, streptococci, and staphylococci; dihydrofolate reductase inhibitor
Description:	Synthetic compound
Year first mentioned:	1945
Highest developmental phase:	Clinical trial in 1945
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	C1=CC(=C(C=C1)C(=O)O)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3
Isomeric SMILES:	C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)C(=O)O
InChI:	InChI=1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)
InChI Key:	PBMSWVPMRUJMPE-UHFFFAOYSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/4806
Main Source:	https://jamanetwork.com/journals/jama/article-abstract/276901