Compound ID | 3281

Update compound information

Azinothricin 

Class: Antimicrobial peptide (hexadepsipeptide)

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Streptococcus pneumoniae, and Clostridium sp.,
Description: Natural product from Streptomyces sp.; also shows anti-tumour activity; a hexadepsipeptide
Institute where first reported: Hoffmann-La Roche Inc
Year first mentioned: 1986
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1021.21
Iso. SMILES: CCC(/C=C(\C)/C1C(CCC(O1)(C(CC)(C(=O)NC2C(OC(=O)C(NC(=O)C3CCCNN3C(=O)C(N(C(=O)C(N(C(=O)C4CCCNN4C2=O)O)COC)C)C)C(C)O)C(C)C)O)O)C)C(=O)/C(=C/C)/C
InChI Key: SWYLPIMCJADFNO-QIFPABMSSA-N
Can. SMILES: C/C=C(\C)/C(=O)C(CC)/C=C(\C)/C1C(C)CCC(C(CC)(C(=O)NC2C(C(C)C)OC(=O)C(C(C)O)NC(=O)C3CCCNN3C(=O)C(C)N(C)C(=O)C(COC)N(C(=O)C4CCCNN4C2=O)O)O)(O)O1
InChI: InChI=1S/C49H80N8O15/c1-13-27(6)38(59)32(14-2)24-29(8)40-28(7)20-21-49(68,72-40)48(67,15-3)47(66)53-37-39(26(4)5)71-46(65)36(31(10)58)52-41(60)33-18-16-22-50-55(33)42(61)30(9)54(11)43(62)35(25-70-12)57(69)44(63)34-19-17-23-51-56(34)45(37)64/h13,24,26,28,30-37,39-40,50-51,58,67-69H,14-23,25H2,1-12H3,(H,52,60)(H,53,66)/b27-13+,29-24+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6442089
Citations:
  • https://pubs.acs.org/doi/10.1021/ol802817t
  • https://www.jstage.jst.go.jp/article/antibiotics1968/39/1/39_1_17/_article/-char/en

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