Avibactam tomilopil (prodrug)

Synonym(s): AV-006  |  AV006  |  AV 006

Class: Beta-lactamase inhibitor

Spectrum of activity:	Gram-negative
Details of activity:	Active against Enterobacterales expressing ESBL, KPC, OXA-48, and AmpC
Combined with other compounds:	Yes
Description:	Synthetic compound; orally bioavailable prodrug; shows no intrinsic antibacterial activity
Year first mentioned:	2018
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CCOC(=O)C(C)(C)COS(=O)(=O)ON1[C@@H]2CC[C@@H](C(=O)N)N(C2)C1=O
Isomeric SMILES:	CCOC(=O)C(C)(C)COS(=O)(=O)ON1[C@@H]2CC[C@H](N(C2)C1=O)C(=O)N
InChI:	InChI=1S/C14H23N3O8S/c1-4-23-12(19)14(2,3)8-24-26(21,22)25-17-9-5-6-10(11(15)18)16(7-9)13(17)20/h9-10H,4-8H2,1-3H3,(H2,15,18)/t9-,10+/m1/s1
InChI Key:	JHSLCXRZVJOZQZ-ZJUUUORDSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/135339165
Main Source:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01389