Compound ID | 3285

Update compound information

Avibactam tomilopil (prodrug)

Synonym(s): AV-006  |  AV006  |  AV 006

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Enterobacterales expressing ESBL, KPC, OXA-48, and AmpC
Combined with other compounds: Yes
Description: Synthetic compound; orally bioavailable prodrug; shows no intrinsic antibacterial activity
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
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Molecular weight: 393.41
Iso. SMILES: CCOC(=O)C(C)(C)COS(=O)(=O)ON1[C@@H]2CC[C@H](N(C2)C1=O)C(=O)N
InChI Key: JHSLCXRZVJOZQZ-ZJUUUORDSA-N
Can. SMILES: CCOC(=O)C(C)(C)COS(=O)(=O)ON1[C@@H]2CC[C@@H](C(=O)N)N(C2)C1=O
InChI: InChI=1S/C14H23N3O8S/c1-4-23-12(19)14(2,3)8-24-26(21,22)25-17-9-5-6-10(11(15)18)16(7-9)13(17)20/h9-10H,4-8H2,1-3H3,(H2,15,18)/t9-,10+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135339165
Citation: https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01389

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