Sudapyridine

Synonym(s): WX-081  |  WX 081  |  WX081

Class: Diarylquinoline 

Details of activity:	Active against Mycobacterium tuberculosis
Description:	Synthetic compound; analogue of bedaquiline; shows favourable pharmacokinetics and reduced toxicity than badaquiline
Institute where first reported:	Shanghai Jiatan Pharmatech Co., Ltd
Year first mentioned:	2022
Highest developmental phase:	Phase 3 (NCT05824871)
Development status:	Active (as of 2024)

Chemical structure(s):
Canonical SMILES:	CN(C)CC[C@@](C1=CC=CC2=C1C=CC=C2)([C@H](C3=CC=CC=C3)C4=CC(=CN=C4OC)C5=CC=C(C=C5)Cl)O
Isomeric SMILES:	CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=CC(=C4)C5=CC=C(C=C5)Cl)OC)O
InChI:	InChI=1S/C34H33ClN2O2/c1-37(2)21-20-34(38,31-15-9-13-25-10-7-8-14-29(25)31)32(26-11-5-4-6-12-26)30-22-27(23-36-33(30)39-3)24-16-18-28(35)19-17-24/h4-19,22-23,32,38H,20-21H2,1-3H3/t32-,34-/m1/s1
InChI Key:	MMUCHWPQRGEHDV-ZFEZZJPFSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/156777270

External links:
Main Source:	https://journals.asm.org/doi/10.1128/spectrum.02477-21