Compound ID | 3286

Update compound information

Sudapyridine

Synonym(s): WX-081  |  WX 081  |  WX081  |  fudapirine

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Mycobacterium tuberculosis
Description: Synthetic compound (diarylquinoline); analogue of bedaquiline; shows favourable pharmacokinetics and reduced toxicity than bedaquiline
Institute where first reported: Shanghai Jiatan Pharmatech Co., Ltd
Year first mentioned: 2022
Highest developmental phase: Phase 3 (NCT05824871)
Development status: Active (as of 2024)
Chemical structure(s):
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Molecular weight: 537.09
Iso. SMILES: CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=CC(=C4)C5=CC=C(C=C5)Cl)OC)O
InChI Key: MMUCHWPQRGEHDV-ZFEZZJPFSA-N
Can. SMILES: CN(C)CC[C@@](C1=CC=CC2=C1C=CC=C2)([C@H](C3=CC=CC=C3)C4=CC(=CN=C4OC)C5=CC=C(C=C5)Cl)O
InChI: InChI=1S/C34H33ClN2O2/c1-37(2)21-20-34(38,31-15-9-13-25-10-7-8-14-29(25)31)32(26-11-5-4-6-12-26)30-22-27(23-36-33(30)39-3)24-16-18-28(35)19-17-24/h4-19,22-23,32,38H,20-21H2,1-3H3/t32-,34-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/156777270
Guide to Pharmacology: fudapirine
Citation: https://journals.asm.org/doi/10.1128/spectrum.02477-21

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