Compound ID | 3287

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Taurolidine

Synonym(s): taurolin

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, and Clostridium perfringens
Description: Synthetic compound; formulates as taurolidine heparin sodium solution to additionally reduce thrombosis
Institute where first reported: Cormedix
Year first mentioned: 1977
Highest development stage: Approved by FDA in 2023
Development status: Approved
Chemical structure(s):
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Molecular weight: 284.36
Iso. SMILES: C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
InChI Key: AJKIRUJIDFJUKJ-UHFFFAOYSA-N
Can. SMILES: C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
InChI: InChI=1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/29566
Guide to Pharmacology: taurolidine
Citations:
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC89943/#:~:text=In%20vitro%2C%20the%20antimicrobial%20agent,not%20effective%20in%20experimental%20endocarditis.
  • https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.1980.tb05210.x
  • https://www.sciencedirect.com/science/article/pii/0261561487900665
  • https://www.sciencedirect.com/science/article/pii/0195670180900572?via%3Dihub

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