Taurolidine

Synonym(s): taurolin

Class: Synthetic small molecule

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Active against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, and Clostridium perfringens
Description:	Synthetic compound; formulates as taurolidine heparin sodium solution to additionally reduce thrombosis
Institute where first reported:	Cormedix
Year first mentioned:	1977
Highest developmental phase:	Approved by FDA in 2023
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
Isomeric SMILES:	C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
InChI:	InChI=1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
InChI Key:	AJKIRUJIDFJUKJ-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/29566

External links:
Main Source:	https://www.sciencedirect.com/science/article/pii/0195670180900572?via%3Dihub
Citations:	https://pmc.ncbi.nlm.nih.gov/articles/PMC89943/#:~:text=In%20vitro%2C%20the%20antimicrobial%20agent,not%20effective%20in%20experimental%20endocarditis. https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.1980.tb05210.x https://www.sciencedirect.com/science/article/pii/0261561487900665