Compound ID | 3289

Update compound information

XF-73 (exeporfinium chloride)

Synonym(s): XF73  |  XF 73

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Membrane-perturbing but non-lytic
Target Pathogen: Active against methicillin-resistant and -susceptible Staphylococcus aureus
Institute where first reported: Destiny Pharma Plc
Year first mentioned: 2023
Highest development stage: Phase 2 (NCT03915470)
Development status: Active (as of 2024)
Chemical structure(s):
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Molecular weight: 694.91
Iso. SMILES: C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=CC4=NC(=C(C5=CC=C(N5)C=C6C=CC2=N6)C7=CC=C(C=C7)OCCC[N+](C)(C)C)C=C4)N3
InChI Key: KZTXNPVFWHWJSH-UHFFFAOYSA-N
Can. SMILES: C[N+](C)(C)CCCOC1=CC=C(C=C1)C2=C3C=CC(=N3)C=C4C=CC(=C(C5=CC=C(C=C5)OCCC[N+](C)(C)C)C6=NC(=CC7=CC=C2N7)C=C6)N4
InChI: InChI=1S/C44H50N6O2/c1-49(2,3)25-7-27-51-37-17-9-31(10-18-37)43-39-21-13-33(45-39)29-35-15-23-41(47-35)44(42-24-16-36(48-42)30-34-14-22-40(43)46-34)32-11-19-38(20-12-32)52-28-8-26-50(4,5)6/h9-24,29-30,45,48H,7-8,25-28H2,1-6H3/q+2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135456186
Guide to Pharmacology: exeporfinium
Citations:
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10369221/
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10386860/
  • https://academic.oup.com/jac/article/64/4/735/704195

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