FNDR-20081

Synonym(s): FND20081  |  FNDR 20081

Class: Synthetic small molecule

Details of activity:	Active against Mycobacterium tuberculosis
Description:	Synthetic compound; derivative of quinoline; shows no cytotoxicity (IC50) towards HepG2 and THP-1 cells at >100 uM
Year first mentioned:	2021
Highest developmental phase:	Preclinical
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC(C)C1=CC=C(C=C1)C2=NC(=NO2)CN3CCN(CC3)C4=CC=NC5=CC(=CC=C54)C6=CN=CC=C6
Isomeric SMILES:	CC(C)C1=CC=C(C=C1)C2=NC(=NO2)CN3CCN(CC3)C4=C5C=CC(=CC5=NC=C4)C6=CN=CC=C6
InChI:	InChI=1S/C30H30N6O/c1-21(2)22-5-7-23(8-6-22)30-33-29(34-37-30)20-35-14-16-36(17-15-35)28-11-13-32-27-18-24(9-10-26(27)28)25-4-3-12-31-19-25/h3-13,18-19,21H,14-17,20H2,1-2H3
InChI Key:	HIQQOKPODUCWTH-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/146279269

External links:
Main Source:	https://www.sciencedirect.com/science/article/pii/S1472979221000548?via%3Dihub
Citation:	https://www.sciencedirect.com/science/article/pii/S0960894X18308564