OTB-658

Synonym(s): OTB658  |  OTB 658

Class: Oxazolidinone

Details of activity:	Active against Mycobacterium tuberculosis; protein synthesis inhibitor
Propensity to select resistant mutants:	Yes, at frequency of 9.09 × 10^-9 to 3.3 × 10^-8 at 4xMIC
Description:	Synthetic compound; shows comparable potency as rifampicin in Mycobacterium tuberculosis infected macrophage cells
Year first mentioned:	2020
Highest developmental phase:	Preclinical (approved Phase 1 clinical trial in China)
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CC(=O)NC[C@H]1[C@@H]2COC3=CC(=C(C=C3N2C(=O)O1)F)N4CCSCC4
Isomeric SMILES:	CC(=O)NC[C@H]1[C@@H]2COC3=C(N2C(=O)O1)C=C(C(=C3)N4CCSCC4)F
InChI:	InChI=1S/C17H20FN3O4S/c1-10(22)19-8-16-14-9-24-15-7-12(20-2-4-26-5-3-20)11(18)6-13(15)21(14)17(23)25-16/h6-7,14,16H,2-5,8-9H2,1H3,(H,19,22)/t14-,16-/m0/s1
InChI Key:	WZAVWVAEARSISR-HOCLYGCPSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/156495313

External links:
Main Source:	https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00500
Citation:	https://journals.asm.org/doi/10.1128/aac.00974-21