Compound ID | 3297

Update compound information

Cefepime + nacubactam

Synonym(s): cefepime + OP0595

Class: Beta-lactam + beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Indirect acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. PBP2 inhibitor
Target Pathogen: Active against Enterobacterales
Combined with other compounds: Yes
Description: Synthetic compound; drug combination; cephalosporin-type beta-lactam
Institute where first reported: Meiji Seika Pharma Co., Ltd.
Year first mentioned: 2015
Highest development stage: Phase 3 (NCT05905055)
Development status: Active (as of 2024)
Chemical structure(s):
Click here for structure editor
Molecular weight: 480.56
Iso. SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
InChI Key: HVFLCNVBZFFHBT-ZKDACBOMSA-N
Can. SMILES: C[N+]1(CCCC1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N
InChI: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5479537
Citations:
  • https://journals.asm.org/doi/10.1128/aac.02184-15?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://academic.oup.com/jac/article/70/11/3032/2364032?login=true

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.