Compound ID | 3297

Update compound information

Cefepime + nacubactam

Synonym(s): cefepime + OP0595

Class: Beta-lactam (cephalosporin) + beta-lactamase inhibitor

Details of activity: Active against Enterobacterales; inhibits PBP2
Combined with other compounds: Yes
Description: Synthetic compound; drug combination; cephalosporin-type beta-lactam
Institute where first reported: Meiji Seika Pharma Co., Ltd.
Year first mentioned: 2015
Highest developmental phase: Phase 3 (NCT05905055)
Development status: Active (as of 2024)
Chemical structure(s):
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Molecular weight: 480.56
Iso. SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
InChI Key: HVFLCNVBZFFHBT-ZKDACBOMSA-N
Can. SMILES: C[N+]1(CCCC1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N
InChI: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5479537
Citations:
  • https://journals.asm.org/doi/10.1128/aac.02184-15?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
  • https://academic.oup.com/jac/article/70/11/3032/2364032?login=true

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