Compound ID | 3298

Update compound information

Ceftibuten + ledaborbactam

Class: Beta-lactam + beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Indirect acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Enterobacterales expressing serine beta-lactamases
Combined with other compounds: Yes
Description: Synthetic compound; drug combination; cephalosporin-type beta-lactam
Year first mentioned: 2022
Highest development stage: Phase 1
Development status: Active
Chemical structure(s):
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Molecular weight: 410.43
Iso. SMILES: C1C=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)/C(=C\CC(=O)O)/C3=CSC(=N3)N)C(=O)O
InChI Key: UNJFKXSSGBWRBZ-BJCIPQKHSA-N
Can. SMILES: C(=C(\C1=CSC(=N1)N)/C(=O)N[C@@H]2C(=O)N3C(=CCS[C@H]23)C(=O)O)/CC(=O)O
InChI: InChI=1S/C15H14N4O6S2/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25)/b6-1-/t10-,13-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5282242
Citations:
  • https://doi.org/10.1093/jac/dkac359
  • https://journals.asm.org/doi/full/10.1128/aac.00934-22?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

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