Compound ID | 331

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LB 11058

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor. Penicillin-binding protein 2a (PBP2a) inhibitor
Target Pathogen: Active against multidrug resistant streptococci and staphylococci
Description: Cephalosporin-type
Institute where first reported: LG Life Sciences, South Korea
Year first mentioned: 2002
Development status: Experimental
Chemical structure(s):
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Molecular weight: 571.01
Iso. SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)/C(=N\O)/C3=C(SC(=N3)N)Cl)C(=O)O)/C=C/SC4=CC(=O)NC(=N4)N
InChI Key: POXQRKGEFBKVOI-OKDNWOHVSA-N
Can. SMILES: C(=C\SC1=CC(=O)NC(=N1)N)/C2=C(C(=O)O)N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\O)/C4=C(Cl)SC(=N4)N
InChI: InChI=1S/C18H15ClN8O6S3/c19-12-8(25-18(21)36-12)9(26-33)13(29)24-10-14(30)27-11(16(31)32)5(4-35-15(10)27)1-2-34-7-3-6(28)22-17(20)23-7/h1-3,10,15,33H,4H2,(H2,21,25)(H,24,29)(H,31,32)(H3,20,22,23,28)/b2-1+,26-9-/t10-,15-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9872839
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310188/pdf/0534.pdf
  • https://doi.org/10.1128/aac.48.11.4322-4327.2004

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