Compound ID | 3319

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Diffusomycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. An oxidative phosphorylation uncoupler
Description: Natural product from Streptomyces albus; belongs to the oxazolomycin group; shows anti-coccidial and anti-viral properties
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 655.78
Iso. SMILES: C[C@H]1C(=O)N(C2([C@@]1([C@H](C[C@@H](C)C(/C=C/C=C/CNC(=O)C(C)(C)C(/C(=C\C=C/C=C/CC3=CN=CO3)/C)O)O)OC)O)COC2=O)C
InChI Key: ZZNSFVQRQDZGGX-KXXCBVSKSA-N
Can. SMILES: C/C(=C/C=C\C=C\CC1=CN=CO1)/C(C(C)(C)C(=O)NC/C=C/C=C/C([C@H](C)C[C@@H]([C@@]2([C@@H](C)C(=O)N(C)C32COC3=O)O)OC)O)O
InChI: InChI=1S/C35H49N3O9/c1-23(15-11-8-9-12-16-26-20-36-22-47-26)29(40)33(4,5)31(42)37-18-14-10-13-17-27(39)24(2)19-28(45-7)35(44)25(3)30(41)38(6)34(35)21-46-32(34)43/h8-15,17,20,22,24-25,27-29,39-40,44H,16,18-19,21H2,1-7H3,(H,37,42)/b11-8-,12-9+,14-10+,17-13+,23-15-/t24-,25+,27?,28+,29?,34?,35-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6438468
Citations:
  • https://www.jstage.jst.go.jp/article/intnaturalprod/1988/0/1988_245/_article/-char/en
  • https://www.sciencedirect.com/science/article/pii/S0960894X08006136?via%3Dihub

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