Compound ID | 3322

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Boholmycin

Class: Aminoglycoside

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Staphylococcus aureus (weak activity), Escherichia coli, Klebsiella pneumoniae, kanamycin-resistant Pseudomonas aeruginosa, and Mycobacterium phlei
Description: Natural product from Streptomyces hygroscopicus H617-25; shows inferior in vivo activity compared to kanamycin and streptomycin in Gram-positive and Gram-negative infection in mice
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 764.69
Iso. SMILES: CNC1C(C(COC1OC2C(C(C(C(C2OC(=O)N)O)OC(=O)N)OC3C(C(C(C(O3)CO)O)N)O)O)OC4C(C(C(C(O4)C(CO)O)O)O)O)O
InChI Key: JPGBWUBDJIISRF-UHFFFAOYSA-N
Can. SMILES: CNC1C(C(COC1OC2C(C(C(C(C2OC(=O)N)O)OC(=O)N)OC3C(C(C(C(CO)O3)O)N)O)O)OC4C(C(C(C(C(CO)O)O4)O)O)O)O
InChI: InChI=1S/C27H48N4O21/c1-31-9-11(36)7(47-25-15(40)13(38)14(39)18(48-25)5(34)2-32)4-45-23(9)49-19-16(41)20(22(52-27(30)44)17(42)21(19)51-26(29)43)50-24-12(37)8(28)10(35)6(3-33)46-24/h5-25,31-42H,2-4,28H2,1H3,(H2,29,43)(H2,30,44)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/164029
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/41/7/41_7_855/_article/-char/en

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