Compound ID | 3329

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19-Deformyl-4'-deoxydesmycosin

Synonym(s): TMC-016  |  TMC016  |  TMC 016

Class: Macrolide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Enterococcus faecalis, Corynebacterium diphtheriae, Mycoplasma pneumoniae, and anaerobic bacteria
Description: Semi-synthetic compound; derived from desmycosin; effective in treating Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus pneumoniae infection in mice when administered orally; more active than its progenitor compound 19-deformyldesmycosin
Institute where first reported: Research Laboratories, Toyo Jozo Co., Ltd.
Year first mentioned: 1989
Development status: Experimental
Chemical structure(s):
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Molecular weight: 727.92
Iso. SMILES: CCC1C(/C=C(\C=C\C(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(CC(O2)C)N(C)C)O)C)C)/C)COC3C(C(C(C(O3)C)O)OC)OC
InChI Key: MMHPQRIORHAXGA-MCDHDYCYSA-N
Can. SMILES: CCC1C(/C=C(/C)\C=C\C(=O)C(C)CC(C)C(C(C)C(CC(=O)O1)O)OC2C(C(CC(C)O2)N(C)C)O)COC3C(C(C(C(C)O3)O)OC)OC
InChI: InChI=1S/C38H65NO12/c1-12-30-26(19-47-38-36(46-11)35(45-10)32(43)25(7)49-38)15-20(2)13-14-28(40)21(3)16-22(4)34(24(6)29(41)18-31(42)50-30)51-37-33(44)27(39(8)9)17-23(5)48-37/h13-15,21-27,29-30,32-38,41,43-44H,12,16-19H2,1-11H3/b14-13+,20-15-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6441972
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/42/6/42_6_903/_pdf/-char/en

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