Compound ID | 3330

Update compound information

19-Deformyldesmycosin

Synonym(s): TMC-014  |  TMC014  |  TMC 014

Class: Macrolide

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Enterococcus faecalis, Corynebacterium diphtheriae, Mycoplasma pneumoniae, and anaerobic bacteria
Description: Semi-synthetic compound; derived from desmycosin; effective in treating Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus pneumoniae infection in mice when administered orally
Institute where first reported: Research Laboratories, Toyo Jozo Co., Ltd.
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 743.92
Iso. SMILES: CCC1C(/C=C(\C=C\C(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)C)C)/C)COC3C(C(C(C(O3)C)O)OC)OC
InChI Key: QPFZVOBGKSRNES-MYCMRBOKSA-N
Can. SMILES: CCC1C(/C=C(/C)\C=C\C(=O)C(C)CC(C)C(C(C)C(CC(=O)O1)O)OC2C(C(C(C(C)O2)O)N(C)C)O)COC3C(C(C(C(C)O3)O)OC)OC
InChI: InChI=1S/C38H65NO13/c1-12-28-25(18-48-38-36(47-11)35(46-10)32(44)24(7)50-38)15-19(2)13-14-26(40)20(3)16-21(4)34(22(5)27(41)17-29(42)51-28)52-37-33(45)30(39(8)9)31(43)23(6)49-37/h13-15,20-25,27-28,30-38,41,43-45H,12,16-18H2,1-11H3/b14-13+,19-15-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6444058
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/42/6/42_6_903/_pdf/-char/en

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