Compound ID | 334

Update compound information

ME1221

Synonym(s): ME-1221  |  ME 1221

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Escherichia coli, Streptococcus pyogenes, Klebsiella pneumoniae, and Proteus vulgaris
Description: Cephalosporin-type with N-alkylpyridiniumthiomethyl side chain
Institute where first reported: Meiji Seika Kaisha (Meiji Seika Pharma., Japan)
Year first mentioned: 1986
Development status: Experimental
Reason dropped: It's activity was equal or less than cefpirome and ceftazidime
Chemical structure(s):
Click here for structure editor
Molecular weight: 604.68
Iso. SMILES: C[N+]1=C2CCCC2=C(C=C1)SCC3=C(N4[C@@H]([C@@H](C4=O)NC(=O)/C(=N/OCC(=O)O)/C5=CSC(=N5)N)SC3)C(=O)[O-]
InChI Key: KAYODKQGOPMBKS-WEQDFQRJSA-N
Can. SMILES: C[N+]1=CC=C(C2=C1CCC2)SCC3=C(C(=O)[O-])N4C(=O)[C@H]([C@H]4SC3)NC(=O)/C(=N/OCC(=O)O)/C5=CSC(=N5)N
InChI: InChI=1S/C24H24N6O7S3/c1-29-6-5-15(12-3-2-4-14(12)29)38-8-11-9-39-22-18(21(34)30(22)19(11)23(35)36)27-20(33)17(28-37-7-16(31)32)13-10-40-24(25)26-13/h5-6,10,18,22H,2-4,7-9H2,1H3,(H4-,25,26,27,31,32,33,35,36)/b28-17+/t18-,22-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9576839
Citations:
  • https://www.sciencedirect.com/science/article/pii/S1198743X14642476#cesec40
  • https://pubmed.ncbi.nlm.nih.gov/1794294/

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