Compound ID | 335

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NB2001

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Cell wall inihibitor which is active against MRSA. It is thought to resist the β-lactamases through ECTA (enzyme catalysed therapeutic activation)
Institute where first reported: New Biotics (Kiadis Pharmaceuticals, Netherlands)
Year first mentioned: 2001
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: NewBiotics was acquired by Celmed Biosciences in 2004 which was then acquired by Kiadis Pharma.
Chemical structure(s):
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Molecular weight: 624.94
Iso. SMILES: ClC=1C=C(Cl)C=CC1OC2=CC=C(Cl)C=C2OCC3=C(C(O)=O)C4C(SC3)[C@@H](C4=O)NC(CC5=CC=CS5)=O
InChI Key: AFZSZPYKFLGVPE-MYIFBMMKSA-N
Can. SMILES: C1=CSC(=C1)CC(=O)N[C@@H]2C(=O)C3C(=C(COC4=CC(=CC=C4OC5=CC=C(C=C5Cl)Cl)Cl)CSC32)C(=O)O
InChI: InChI=1S/C27H20Cl3NO6S2/c28-14-3-5-18(17(30)8-14)37-19-6-4-15(29)9-20(19)36-11-13-12-39-26-23(22(13)27(34)35)25(33)24(26)31-21(32)10-16-2-1-7-38-16/h1-9,23-24,26H,10-12H2,(H,31,32)(H,34,35)/t23?,24-,26?/m1/s1
External links:
Citations:
  • https://journals.asm.org/doi/10.1128/aac.46.5.1262-1268.2002
  • https://journals.asm.org/doi/10.1128/aac.46.5.1262-1268.2002

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