Compound ID | 3371

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Amythiamicin

Class: Protein synthesis inhibitor

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus including multidrug-resistant and methicillin resistant isolates; targets elongation factor Tu (ef-Tu)
Description: Natural product from Amycolatopsis sp.
Year first mentioned: 1994
Development status: Experimental
Chemical structure(s):
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Molecular weight: 1182.43
Iso. SMILES: CC1=C2C(=O)NC(C3=NC(=CS3)C(=O)NCC(=O)NC(C4=NC(=CS4)C5=NC(=CS5)C6=C(C=CC(=N6)C7=NC(=CS7)C8=NC(CO8)C(=O)N9CCCC9C(=O)N)C3=NC(=CS3)C(=O)NC(C(=N2)S1)CC(=O)NC)C(C)C)C(C)C
InChI Key: BAGBLRBLZUISAJ-UHFFFAOYSA-N
Can. SMILES: CC(C)C1C2=NC(=CS2)C3=NC(=CS3)C4=NC(=CC=C4C5=NC(=CS5)C(=O)NC(CC(=O)NC)C6=NC(=C(C)S6)C(=O)NC(C(C)C)C7=NC(=CS7)C(=O)NCC(=O)N1)C8=NC(=CS8)C9=NC(CO9)C(=O)N%10CCCC%10C(=O)N
InChI: InChI=1S/C50H51N15O8S6/c1-20(2)35-48-61-31(19-78-48)46-57-27(15-75-46)38-23(9-10-24(54-38)45-60-30(18-76-45)43-56-26(14-73-43)50(72)65-11-7-8-32(65)39(51)68)44-58-29(17-74-44)41(70)55-25(12-33(66)52-6)47-64-37(22(5)79-47)42(71)63-36(21(3)4)49-59-28(16-77-49)40(69)53-13-34(67)62-35/h9-10,15-21,25-26,32,35-36H,7-8,11-14H2,1-6H3,(H2,51,68)(H,52,66)(H,53,69)(H,55,70)(H,62,67)(H,63,71)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/198789
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/47/10/47_10_1153/_article
  • https://www.jstage.jst.go.jp/article/antibiotics1968/47/6/47_6_668/_article/-char/en

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