Compound ID | 3392

Update compound information

Cefepime + Ftortiazinon (fluorothyazinone)

Class: Beta-lactam (cephalosporin) + antivirulence (T3SS inhibitor)

Spectrum of activity: Gram-negative
Details of activity: Active against Pseudomonas aeruginosa; intended indication for complicated urinary tract infection
Combined with other compounds: Yes
Description: Drug combination
Institute where first reported: Gamaleya Research Institute of Epidemiology and Microbiology
Year first mentioned: 2022
Highest developmental phase: Phase 2
Development status: Unknown
Chemical structure(s):
Cefepime
Click here for structure editor
Molecular weight: 480.56
Iso. SMILES: C[N+]1(CCCC1)CC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-]
InChI Key: HVFLCNVBZFFHBT-ZKDACBOMSA-N
Can. SMILES: C[N+]1(CCCC1)CC2=C(C(=O)[O-])N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\OC)/C4=CSC(=N4)N
InChI: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
Ftortiazinon
Click here for structure editor
Molecular weight: 421.42
Iso. SMILES: CCOC1=C(C=CC(=C1)CN2C(=O)CSC(=N2)C(=O)NC3=C(C=C(C=C3)F)F)O
InChI Key: DAKWAZGLXWXDBB-UHFFFAOYSA-N
Can. SMILES: CCOC1=CC(=CC=C1O)CN2C(=O)CSC(=N2)C(=O)NC3=CC=C(C=C3F)F
InChI: InChI=1S/C19H17F2N3O4S/c1-2-28-16-7-11(3-6-15(16)25)9-24-17(26)10-29-19(23-24)18(27)22-14-5-4-12(20)8-13(14)21/h3-8,25H,2,9-10H2,1H3,(H,22,27)
External links:
Citation:

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.