Compound ID | 3396

Update compound information

Reltecimod

Synonym(s): AB103  |  AB 103  |  AB-103  |  p2TA

Agent Type: Synthetic; Indirect acting;
Spectrum of activity: Gram-positive
Mechanism of action: Attenuates inflammatory response of hosts from pathogen infections by binding to superantigens interfering their ability to bind CD28 or binding directly to CD28 (interference with CD28 signalling prevents release of cytokines)
Target Pathogen: Active against Staphylococcus aureus; intended indication forS. aureus necrotizing soft tissue infection, acute kidney injury, and peritonitis
Description: Synthetic oligopeptide; shows homology to CD28 residues; antagonizes interaction with CD28 on T cells; an immunomodulator agent
Institute where first reported: Atox Bio
Year first mentioned: 2011
Highest development stage: Phase 3 (NCT03403751)
Development status: Inactive
Reason dropped: Poor enrolment of patients during clinical trial
Chemical structure(s):
Click here for structure editor
Molecular weight: 1037.19
Iso. SMILES: CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@@H](C)N
InChI Key: VRNHFZYMPDKTBS-WYUJEMNCSA-N
Can. SMILES: CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@@H](C)N
InChI: InChI=1S/C46H72N10O15S/c1-22(2)18-30(52-39(63)29(15-17-72-8)50-43(67)34-10-9-16-56(34)45(69)33(21-57)54-37(61)24(5)47)42(66)55-36(23(3)4)44(68)48-25(6)38(62)51-31(19-27-11-13-28(58)14-12-27)41(65)53-32(20-35(59)60)40(64)49-26(7)46(70)71/h11-14,22-26,29-34,36,57-58H,9-10,15-21,47H2,1-8H3,(H,48,68)(H,49,64)(H,50,67)(H,51,62)(H,52,63)(H,53,65)(H,54,61)(H,55,66)(H,59,60)(H,70,71)/t24-,25+,26-,29+,30+,31+,32+,33+,34+,36+/m1/s1
External links:
Guide to Pharmacology: reltecimod
Citations:
  • https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001149
  • https://access.portico.org/Portico/auView?auId=ark:%2F27927%2Fpjbf78x6tds

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