Compound ID | 3401

Update compound information

CC-11050

Synonym(s): Dovramilast  |  AMR-634  |  AMR 634  |  AMR634

Class: Immunomodulator agent

Details of activity: Active against Mycobacterium tuberculosis; targets host phosphodiesterase 4 (PDE4) to regulate inflammatory response
Description: Synthetic compound; improves bacterial clearance and moderates infection induced inflammation with isoniazid in rabbits with TB
Institute where first reported: Medicines Development for Global Health
Year first mentioned: 2016
Highest developmental phase: Phase 2 (NCT03807362)
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 472.56
Iso. SMILES: CCOC1=CC(=CC=C1OC)[C@@H](CS(=O)(=O)C)N2CC3=CC=CC(=C3C2=O)NC(=O)C4CC4
InChI Key: QDZOBXFRIVOQBR-LJQANCHMSA-N
Can. SMILES: CCOC1=CC(=CC=C1OC)[C@@H](CS(=O)(=O)C)N2CC3=CC=CC(=C3C2=O)NC(=O)C4CC4
InChI: InChI=1S/C24H28N2O6S/c1-4-32-21-12-16(10-11-20(21)31-2)19(14-33(3,29)30)26-13-17-6-5-7-18(22(17)24(26)28)25-23(27)15-8-9-15/h5-7,10-12,15,19H,4,8-9,13-14H2,1-3H3,(H,25,27)/t19-/m1/s1
External links:
Guide to Pharmacology: dovramilast
Citation: https://doi.org/10.1016/j.ebiom.2016.01.015

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