SQ109

Synonym(s): SQ-109  |  SQ 109  |  MMV687273

Class: Ethylenediamine

Details of activity:	Active against Mycobacterium tuberculosis; mycolate transporter (MmpL3) inhibitor
Description:	Synthetic compound; contains 1,2 ethylenediamine (ethambutol) pharmacophore
Institute where first reported:	Suquella Inc.
Year first mentioned:	2005
Highest developmental phase:	Phase 2
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CC(=CCC/C(=C/CNCCNC1C2CC3CC(C2)CC1C3)/C)C
Isomeric SMILES:	CC(=CCC/C(=C/CNCCNC1C2CC3CC(C2)CC1C3)/C)C
InChI:	InChI=1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
InChI Key:	JFIBVDBTCDTBRH-REZTVBANSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5274428
Guide to Pharmacology:	SQ-109
Main Source:	https://academic.oup.com/jac/article/56/5/968/893073
Citations:	https://www.nature.com/articles/s42003-022-03693-2 https://doi.org/10.2217/fmb.12.56