Compound ID | 3412

Update compound information

CRS0393

Synonym(s): CRS-0393  |  CRS 0393

Class: Mycolic acid synthesis inhibitor

Details of activity: Active against Mycobacterium abscessus and Mycobacterium tuberculosis including strains resistant to fluoroquinolone, linezolid, macrolide, tetracycline, or beta-lactams; Mycolate transporter MmpL3 inhibitor
Description: Synthetic compound; a benzothiazole amide
Year first mentioned: 2018
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 383.34
Iso. SMILES: CC12CCCC(C1)(CCC2)C(=O)NC3=NC4=C(S3)C(=CC(=C4)Cl)Cl
InChI Key: KHJLLQYNCQNVKV-UHFFFAOYSA-N
Can. SMILES: CC12CCCC(CCC1)(C2)C(=O)NC3=NC4=C(C(=CC(=C4)Cl)Cl)S3
InChI: InChI=1S/C18H20Cl2N2OS/c1-17-4-2-6-18(10-17,7-3-5-17)15(23)22-16-21-13-9-11(19)8-12(20)14(13)24-16/h8-9H,2-7,10H2,1H3,(H,21,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/138319692
Citations:
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC9892229/
  • https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02231/full
  • https://www.sciencedirect.com/science/article/pii/S0960894X18307005?via%3Dihub

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