Compound ID | 342

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RWJ-333441

Synonym(s): MC-04,546

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Combined with other compounds: Could be combined with aztreonam, fosfomycin, gentamicin or levofloxacin for empiric therapy
Description: Cephalosporin-type
Institute where first reported: Microcide Pharmaceuticals; Essential Therapeutics, USA (Ceased)
Year first mentioned: 2000
Development status: Experimental
Reason dropped: Essential Therapeutics closed down in 2004
Chemical structure(s):
Click here for structure editor
Molecular weight: 568.68
Iso. SMILES: C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)/C(=N\O)/C3=NSC(=N3)N)C(=O)O)SC4=C(N=CC=C4)CSCCN
InChI Key: SCSMAWFISUMSTO-ZTJYIHJESA-N
Can. SMILES: C1=CN=C(CSCCN)C(=C1)SC2=C(C(=O)O)N3C(=O)[C@H]([C@H]3SC2)NC(=O)/C(=N\O)/C4=NSC(=N4)N
InChI: InChI=1S/C19H20N8O5S4/c20-3-5-33-6-8-9(2-1-4-22-8)35-10-7-34-17-12(16(29)27(17)13(10)18(30)31)23-15(28)11(25-32)14-24-19(21)36-26-14/h1-2,4,12,17,32H,3,5-7,20H2,(H,23,28)(H,30,31)(H2,21,24,26)/b25-11-/t12-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135529042
Citations:
  • https://doi.org/10.1016/S0968-0896(02)00431-5
  • https://doi.org/10.1128/aac.47.6.2043-2046.2003

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