Compound ID | 343
RWJ 333442 (Prodrug of RWJ-333441)
Class: Beta-lactam (cephalosporin)
| Spectrum of activity: | Gram-negative |
| Details of activity: | Cell wall inhibitors; active against a broad spectrum of Gram positive bacteria including resistant strains such as MRSA but not MRCR S. aureus |
| Combined with other compounds: | Could be combined with aztreonam, fosfomycin, gentamicin or levofloxacin for empiric therapy |
| Institute where first reported: | Microcide Pharmaceuticals; Essential Therapeutics, USA (Ceased) |
| Year first mentioned: | 2000 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | Essential Therapeutics closed down in 2004 |
| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/substance/273482665 |
| Citation: | https://journals.asm.org/doi/full/10.1128/aac.47.6.2043-2046.2003?origin=publication_detail%3D |
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