Compound ID | 3434

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Lactonamycin

Class: Natural product antibiotic (naphthoquinone)

Spectrum of activity: Gram-positive
Details of activity: Active against methicillin-resistant and -susceptible Staphylococcus aureus, Streptococcus faecalis, Streptococcus pyogenes, Corynebacterium bovis,Enterococcus faecium, and Enterococcus faecalis
Description: Natural product from Streptomyces rishiriensis; also shows anti-tumour properties
Year first mentioned: 1999
Development status: Experimental
Chemical structure(s):
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Molecular weight: 569.51
Iso. SMILES: C[C@H]1[C@H](CC[C@@H](O1)O[C@@]23CO[C@@]4([C@@]2(C(=O)C5=C(C3=O)C=C6C=C(C7=C(C6=C5O)CN(C7=O)C)O)OC(=O)C4)OC)O
InChI Key: XFQJOLWXLJXJSV-VUAGTGNDSA-N
Can. SMILES: C[C@H]1[C@H](CC[C@@H](O1)O[C@]23CO[C@]4(CC(=O)O[C@@]34C(=O)C5=C(C6=C7CN(C)C(=O)C7=C(C=C6C=C5C2=O)O)O)OC)O
InChI: InChI=1S/C28H27NO12/c1-11-15(30)4-5-18(39-11)41-26-10-38-27(37-3)8-17(32)40-28(26,27)24(35)21-13(23(26)34)6-12-7-16(31)20-14(19(12)22(21)33)9-29(2)25(20)36/h6-7,11,15,18,30-31,33H,4-5,8-10H2,1-3H3/t11-,15-,18-,26+,27-,28-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10370774
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/52/3/52_3_269/_article

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