Compound ID | 3446

Update compound information

CJ-15,801

Synonym(s): CJ-15801  |  CJ15801

Class: CoA synthesis inhibitor

Spectrum of activity: Gram-positive
Details of activity: Only active against Staphylococcus aureus; coenzyme A (CoA) synthesis inhibitor (mimics the native reaction intermediate inducing a tight-binding with enzyme)
Description: Natural product from Seimatosporium sp.; an antimetabolite of the vitamin synthesis pathway
Institute where first reported: Pfizer Pharmaceuticals, Inc.
Year first mentioned: 2001
Development status: Experimental
Chemical structure(s):
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Molecular weight: 217.22
Iso. SMILES: CC(C)(CO)[C@H](C(=O)N/C=C/C(=O)O)O
InChI Key: HWKKTJQAKVPKTK-SDLBARTOSA-N
Can. SMILES: CC(C)(CO)[C@H](C(=O)N/C=C/C(=O)O)O
InChI: InChI=1S/C9H15NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h3-4,7,11,14H,5H2,1-2H3,(H,10,15)(H,12,13)/b4-3+/t7-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6917384
Citations:
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC3361698/
  • https://www.sciencedirect.com/science/article/pii/S1074552112001366?via%3Dihub
  • https://www.jstage.jst.go.jp/article/antibiotics1968/54/12/54_12_1060/_article/-char/en

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