Compound ID | 345
RWJ-442831 (Prodrug of RWJ-54428)
Class: Beta-lactam (cephalosporin)
| Spectrum of activity: | Gram-negative |
| Details of activity: | Cell wall inhibitors; active against a broad spectrum of Gram positive bacteria such as MRSA |
| Combined with other compounds: | Could be combined with aztreonam, fosfomycin, gentamicin or levofloxacin for empiric therapy |
| Institute where first reported: | Microcide Pharmaceuticals; Essential Therapeutics, USA (Ceased); Johnson & Johnson Pharmaceutical |
| Year first mentioned: | 2000 |
| Highest developmental phase: | Preclinical |
| Development status: | Inactive |
| Reason Dropped: | The collaboration between Johnson and Johnson Pharma and Essential Therapeutics which seems to have stopped with the closure of Essential Therapeutics |
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