Compound ID | 3450

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Pseudopyronine B

Synonym(s): Sch 419560

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Additionally a fatty acid synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus
Description: Natural product from Pseudomonas fluorescens; also shows activity against Escherichia coli overexpressing RpoE
Institute where first reported: Schering-Plough Research Institute
Year first mentioned: 2002
Development status: Experimental
Chemical structure(s):
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Molecular weight: 294.43
Iso. SMILES: CCCCCCCC1=CC(=C(C(=O)O1)CCCCCC)O
InChI Key: SJGBVXPXTMNDDG-UHFFFAOYSA-N
Can. SMILES: CCCCCCCC1=CC(=C(CCCCCC)C(=O)O1)O
InChI: InChI=1S/C18H30O3/c1-3-5-7-9-10-12-15-14-17(19)16(18(20)21-15)13-11-8-6-4-2/h14,19H,3-13H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54710733
Citations:
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC9686599/#:~:text=indicated%20that%20the%20antibacterial%20mechanism,strong%20antibacterial%20activity%20against%20S.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC5000868/#sec45
  • https://www.jstage.jst.go.jp/article/antibiotics1968/55/2/55_2_215/_article/-char/en

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