Compound ID | 3453

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Altersetin 

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Enterococcus faecium, and Enterococcus faecalis
Description: Natural product from fungi Alternaria sp.; effective in treating mice with sepsis at 10-25 mg/kg but toxic at >25 mg/kg
Institute where first reported: Bayer AG, Pharma Research
Year first mentioned: 2002
Development status: Experimental
Chemical structure(s):
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Molecular weight: 399.52
Iso. SMILES: C/C=C/C=C/C1C=CC2CC(CCC2C1(C)/C(=C/3\C(=O)C(NC3=O)C(C)O)/O)C
InChI Key: AIFXMSDWXBFQTF-SNXGECCISA-N
Can. SMILES: C/C=C/C=C/C1C=CC2CC(C)CCC2C1(C)/C(=C/3\C(=O)C(C(C)O)NC3=O)/O
InChI: InChI=1S/C24H33NO4/c1-5-6-7-8-17-11-10-16-13-14(2)9-12-18(16)24(17,4)22(28)19-21(27)20(15(3)26)25-23(19)29/h5-8,10-11,14-18,20,26,28H,9,12-13H2,1-4H3,(H,25,29)/b6-5+,8-7+,22-19-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/54724952
Citation: https://www.jstage.jst.go.jp/article/antibiotics1968/55/10/55_10_881/_article/-char/en

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