Compound ID | 3456

Update compound information

Erythromycin G

Class: Macrolide

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Enterococcus faecalis, Klebsiella pneumoniae (only Gram-negative it is active against), Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
Description: Natural product from Saccharopolyspora erythraea
Year first mentioned: 2003
Development status: Experimental
Chemical structure(s):
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Molecular weight: 733.93
Iso. SMILES: CC[C@@H]1[C@@H]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)CO)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)C
InChI Key: ZQLOQWOXRVAVOI-NUNOGRHOSA-N
Can. SMILES: CC[C@@H]1[C@H](C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@](C)([C@@H]([C@@H](C)[C@@H]([C@@H](CO)C(=O)O1)O[C@H]2C[C@](C)([C@H]([C@H](C)O2)O)OC)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)O)O
InChI: InChI=1S/C37H67NO13/c1-13-26-20(4)29(41)21(5)28(40)18(2)15-36(8,45)33(51-35-30(42)25(38(10)11)14-19(3)47-35)22(6)31(24(17-39)34(44)49-26)50-27-16-37(9,46-12)32(43)23(7)48-27/h18-27,29-33,35,39,41-43,45H,13-17H2,1-12H3/t18-,19-,20+,21+,22+,23+,24-,25+,26-,27+,29+,30-,31+,32+,33-,35+,36-,37-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10032881
Citations:
  • https://pdf.sciencedirectassets.com/271397/1-s2.0-S0968089608X00082/1-s2.0-S0968089608001892/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEP3%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIDzYjt7f0fEu85xWlxN11kvGm1NHvLusUsDPu6%2BOG8g5AiEA%2BTTkgIR9LUMP%2FOJ7Ju1M2glMTMxgk30TkInolzKFqYEqswUIFRAFGgwwNTkwMDM1NDY4NjUiDBNIENOv%2BsmUz17CIyqQBV8Mhhfb%2F5jc3z8Qe8WkYYCM31heV%2FCLzgNuFZdIkBfF%2BUSWhINn%2FYie5y8Yi%2FPZQlhDBGvJ8%2FW%2BnJipIIqYwaaEgyp19vPVMZcgET%2BEqsjC6xyK9XtsFyrbLwWqgsBfKdRHPk0Xjn2jCrTDz4vNuR2VO5OLEe%2Fskcsly9jqJ2h6T%2Fdt56cmi9EswEQ82l5gLDHM3Ywdk3C29sJZUai7IsV7rIAJI8Zmy7JY2lvh4%2FfxjjUiPBg%2BaitEoUgccRkwBLpydST8QXDEhY2AvPH0spA3oFTtrFLNi7qbAj5S84Ii%2By0nsqhUgORZYYB4YSHa2KBYK0OYaifsm4GF7IEgXzZrxrreg7kgxg6sRPjcdYVVU9kUUYajaZG3IuuR4Xnv2x1BmqL4pQKZznC9eUvMf31fFvghME%2FT%2Fs7axS7aNvoKY1ZyoXQqdiwcE94j4d0PnF83zX0MKTRUWur7qgwuaGJhkS3VnAbHTpAElqPcD1vq58ZfwSY7JJmtB6b%2FId7Fyl80ycK8lySwdCmnaer%2B%2BNRY1U%2FjSNdrfojdQIiOWjfJ0PvmGXscCmyOjKswY35bLZ2%2BiEvBxJTXmUts81Yy%2F0hD6NAgdk0iZKIMl7jYndfwUe%2FkJFnC5JuYqbzxKAEUcw499Q4CgXIjSOBFB9q2IOaAdKqkjpCRVXBjyCesw6Blbt8GaFrd7vkUqxkCPxBoydlLzq02x%2B%2BxPyXlTrZ0zsJ1BZtoNoN9S%2F4%2FZGmsFJ97X838eVJGjODaK%2F0z2yKvvItApifX%2BIhNn2HM1%2BDRzQBP1fUd0hlPwaEPeF74VS8TjON7Jpjm2hSkZQg3MhzSTqmTCYv80IjbQsme7iZIa8p%2B%2ByRBpvy3bbL9J9WBUKrEMM7kgr0GOrEB8YRMlY9SWytq6OM%2FoSB9U8gZcIOBqk5WUmPovgluNMFqBTm0qEtF3w%2BjbYmX6Grp1u9q9ih5tsi%2Bt2gC0HsjRYszomre7fHp0%2F7pbWS5XvmeF4AmgjRwpBwk5hZOaEGAG8nw5XYjjbGK00UY%2BsDQ8IELtUGBh%2FQJsMlOjrHcFRhCyqU4CZ9FGLWkmnUN9WsE5kEQKcYQ0NXEdAzPyKmw7SQdXHVv50lhtN1aDNHIwCsl&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20250203T130631Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYYFO7NZMP%2F20250203%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=270239a7c958a15b57b28e01232f2f0cb6a2cdfe7761bc1bf044418c9e826355&hash=8925fb366665518b6ff72842d865801d84b43ef78d1f3083174b0aadc21cfc3a&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0968089608001892&tid=spdf-520d6a49-0ecc-4c8c-84d9-617095f5c92e&sid=6a45a47b78779942164be1998037cc165e29gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=1d045f52015205555e5503&rr=90c2a383ba5beb18&cc=gb
  • https://www.jstage.jst.go.jp/article/antibiotics1968/56/3/56_3_280/_article/-char/en

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