Compound ID | 3460

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Carnosol 

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against vancomycin-resistant Enterococcus faecium and Enterococcus faecalis, and methicillin-resistant and -susceptible Staphylococcus aureus
Description: Natural product from Salvia officinalis (sage); no intrinsic antibacterial activity; potentiates aminoglycosides
Year first mentioned: 2007
Development status: Experimental
Chemical structure(s):
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Molecular weight: 330.42
Iso. SMILES: CC(C)C1=C(C(=C2C(=C1)[C@@H]3C[C@@H]4[C@@]2(CCCC4(C)C)C(=O)O3)O)O
InChI Key: XUSYGBPHQBWGAD-PJSUUKDQSA-N
Can. SMILES: CC(C)C1=C(C(=C2C(=C1)[C@@H]3C[C@H]4C(C)(C)CCC[C@@]42C(=O)O3)O)O
InChI: InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/442009
Citation: https://www.jstage.jst.go.jp/article/bpb/30/2/30_2_287/_article/-char/en

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